Acid-Base Systems -- A Mathematical Toolkit

Simple Closed-Form Equations

Given: N-protic acid HNA
  or zwitterionic acid HNA+Z     with Z≥1

specified by N dissociation constants: K1, K2 to KN.

The pH dependence of the acid is then characterized by the following easy-to-plot functions:1

(1.1) buffer capacity:
(1.2) buffer intensity:
(1.3) 1st derivative of β:

Notation and abbreviations:2

(2.1) H+ concentration: x = [H+] = 10-pH
(2.2) equivalent fraction: n ≡ CB/CT
(2.3) total amount of acid: CT
(2.4) total amount of strong base: CB
(2.5) pure-water balance: w(x) ≡ [OH-] – [H+] = Kw/x – x
(2.6) self-ionization constant: Kw = 10-14    (at 25 °C)
(2.7) charge of highest protonated acid species: Z

Common acids are characterized by Z = 0; only zwitterionic acids (e.g. amino acids) are identified by Z ≥ 1. The parameter Z enters only 1.1 as a constant shift of the buffer capacity.

Moments YL. The main building blocks of the formulas are the so-called moments Y1, Y2 and Y3, which are defined as weighted sums over ionization fractions aj from j=0 to N:

(3)   YL(x)  ≡  j L aj(x)

In particular, we have:

(3.1)   Y0  =  a0 + a1 + … + aN  =  1 mass balance
(3.2)   Y1  =  a1 + 2a2 + … + N aN enters buffer capacity
(3.3)   Y2  =  a1 + 4a2 + … + N2aN enters buffer intensity β
(3.4)   Y3  =  a1 + 8a2 + … + N3aN enters 1st derivative of β

Ionization Fractions. To recapitulate: An N-protic acid is completely specified by the acid’s N dissociation or acidity constants K1, K2 to KN. The ionization fractions aj rely on these acidity constants in the following way:

(4)   with

where kj are the cumulative equilibrium constants (as products of acidity constants):

(5)   k0 = 1,    k1 = K1,    k2 = K1K2,    …    kN = K1K2…KN

The aj’s are the smallest building blocks of our mathematical toolkit.

Speciation. The equilibrium distribution of the acid species [j] is closely related to the ionization fractions:

(6)   [j] = CT aj   where [j] ≡ [HN-j AZ-j] (for j = 0,1, … , N)

Here, [0] represents the highest protonated species and [N] the fully deprotonated species. The symbol j is an integer that also indicates the charge of the species:

(7)   charge of species [j]: zj = Z – j

Summary. The following scheme summarizes the modular structure of the general equations:

set of mathematical equations for polyprotic acids

What we call ‘titration curve’ is just the (normalized) buffer capacity. It represents the equivalent fraction as function of pH: n = n(pH).3 The 1st derivative of the buffer capacity is the buffer intensity:

(8)   buffer intensity β  =  buffer capacity  =  n(pH)

Equivalence Points (EP).  Equation (1.1) can also be used to plot curves EPs and semi-EPs into pH-CT diagrams.

Examples for N = 1, 2 and 3

The analytical formulas will be applied to four common acids, which are characterized by the following acidity constants (where pKj = –lg Kj):

Acid Formula Type pK1 pK2 pK3
acetic acid CH3COOH HA 4.76    
carbonic acid4 H2CO3 H2A 6.35 10.33  
phosphoric acid H3PO4 H3A 2.15 7.21 12.35
citric acid C6H8O7 H3A 3.13 4.76 6.4

Diagrams

Ionization Fractions aj based on 4:

ionization fractions of four common acids

Moments YL based on 3:

moments Y1 to Y4 of four common acids

[Note: For the monoprotic acid HA – in the top-left diagram – all four curves are identical.]

Buffer capacities (i.e. titration curves) based on 1.1 for different amounts CT of acid:5

titration curves of four common acids

The Y1-curve (in dark blue) describes the asymptotic case of infinitely large CT (i.e. highly-concentrated acids).

Buffer intensity β (green curves) based on 1.2 and its first derivative (red curves) based on 1.3:

buffer intensity of four common acids

In addition: buffer capacities (i.e. titration curves) are shown as blue curves.

Final Note

The presented mathematical toolkit provides a better understanding of the acid-base system. But it will and can never replace numerical models like PhreeqC or aqion, which are able to handle real-world problems (including activity corrections, aqueous complex formation, etc.).

Remarks & Footnotes

  1. The mathematical derivation is provided as pdf and/or PowerPoint

  2. Square brackets [..] denote molar concentrations (in contrast to activities, which are expressed by curly braces {..}). 

  3. In textbooks, the equivalent fraction is often abbreviated by f

  4. In hydrochemistry, it is common practice to use the composite carbonic acid, H2CO3* = CO2(aq) + H2CO3 instead of the true carbonic acid. 

  5. Negative values of n mimic the withdrawal of the strong base from the solution or the addition of a strong, monoprotic acid (e.g. HCl). 

[last modified: 2018-03-24]